Differentially expressed miRNAs in cancer-stem-like cells: markers for tumor cell aggressiveness of pancreatic cancer
作者： Bin Bao , Shadan Ali , Aamir Ahmad , Yiwei Li , Sanjeev Banerjee
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摘要: Pancreatic cancer (PC) is one of the most deadly cancers. The higher mortality in part due to treatment resistance and early onset metastasis. existence cancer-stem-like cells (CSLCs) has been widely accepted be responsible for tumor aggressiveness PC. Emerging evidence suggests that CSLCs have capacity increased cell growth, migration/invasion, metastasis, resistance, which leads poor clinical outcome. However, molecular role development progression poorly understood. Therefore, mechanistic understanding, targeted killing may provide a newer therapeutic strategy It well microRNAs (miRNAs) play critical roles during through deregulation multiple genes. Moreover, deregulated expression miRNAs also key regulation CSLC characteristics functions. Here we show isolated CD44+/CD133+/EpCAM+ (trip...
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