Analysis of Driver Mutations in Female Non-Smoker Asian Patients with Pulmonary Adenocarcinoma
作者： Shengxiang Ren , Peng Kuang , Limou Zheng , Chunxia Su , Jiayu Li
DOI: 10.1007/S12013-012-9384-8
关键词:
摘要: Previous studies have revealed that EGFR mutation and/or EML4–ALK gene fusion rate was higher in the non-smoker Asian females with pulmonary adenocarcinoma. The aim of this study is to determine distribution known oncogenic driver mutations female patients 104 consecutively resected lung adenocarcinomas from 396 (less than 100 cigarettes a lifetime) at single institution (Tongji University, Shanghai, China) were analyzed for EGFR, EML4−ALK, KRAS, HER2, BRAF, and PIK3CA. 73 (70.2 %) tumors harbored mutations; among these, 28 deletions exon 19, 44 L858R missense changes, eight T790M mutations. 10 (9.6 %) EML4−ALK fusions, two KRAS mutations, BRAF PI3K A majority mutually exclusive, except mutation, one fusions mutation. Thus, 82.7 % (86 104; 95 % CI, 75.4–90.0 %) found harbor well-known five genes. Lung cancer non-smoking distinct entity, subgroup being developed by prospective examination population will be helpful devising targeted therapy patients.
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