Modulación de la expresión de enzimas del citocromo P450 hepáticas durante las etapas fetal y pediátrica
作者： Dora Molina Ortiz , Adriana Miriam Domínguez Ramírez , Rafael Camacho Carranza , Araceli Vences Mejía
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摘要: The Cytochromes P450 (CYP450) are the principal enzymes of phase I involved in metabolism xenobiotics and endogenous substrates. CYP450 1, 2 3 families play a crucial role excretion drugs. Members 1 absent or low concentration fetal stage; their expression increased after birth until they reach highest quantity adult phase. While members family major human liver at all stages development. Changes different period development can contribute to drug response / toxicological effects them. This review integrates information about hepatic during adulthood.
参考文章(27)
Elda María del Rocio Coutiño Rodríguez, Antonio Purata, Pedro Hernández Cruz, CITOCROMO P450 BIOMARCADOR DE EXPOSICIÓN TERAPEÚTICO-TOXICOLÓGICO -CARCINOGÉNICO REB. Revista de educación bioquímica. ,vol. 29, pp. 39- 52 ,(2010)
Isabel Vieira, Michelle Sonnier, Thierry Cresteil, Developmental expression of CYP2E1 in the human liver. Hypermethylation control of gene expression during the neonatal period. FEBS Journal. ,vol. 238, pp. 476- 483 ,(1996) , 10.1111/J.1432-1033.1996.0476Z.X
Curtis J. Omiecinski, Paola Costa, Carrie A. Redlich, Induction and Developmental Expression of Cytochrome P450IA1 Messenger RNA in Rat and Human Tissues: Detection by the Polymerase Chain Reaction Cancer Research. ,vol. 50, pp. 4315- 4321 ,(1990)
Oliver H. Tam, Alexei A. Aravin, Paula Stein, Angelique Girard, Elizabeth P. Murchison, Sihem Cheloufi, Emily Hodges, Martin Anger, Ravi Sachidanandam, Richard M. Schultz, Gregory J. Hannon, Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes Nature. ,vol. 453, pp. 534- 538 ,(2008) , 10.1038/NATURE06904
Masanori Sono, Mark P. Roach, Eric D. Coulter, John H. Dawson, Heme-Containing Oxygenases Chemical Reviews. ,vol. 96, pp. 2841- 2888 ,(1996) , 10.1021/CR9500500
Tomonori Tateishi, Hironori Nakura, Masako Asoh, Minoru Watanabe, Masami Tanaka, Toshio Kumai, Sachio Takashima, Susumu Imaoka, Yoshihiko Funae, Yoshiyasu Yabusaki, Tetsuya Kamataki, Shinichi Kobayashi, A COMPARISON OF HEPATIC CYTOCHROME P450 PROTEIN EXPRESSION BETWEEN INFANCY AND POSTINFANCY Life Sciences. ,vol. 61, pp. 2567- 2574 ,(1997) , 10.1016/S0024-3205(97)01011-4
Dan Lacroix, Michelle Sonnier, Arlette Moncion, Gerard Cheron, Thierry Cresteil, Expression of CYP3A in the human liver--evidence that the shift between CYP3A7 and CYP3A4 occurs immediately after birth. FEBS Journal. ,vol. 247, pp. 625- 634 ,(1997) , 10.1111/J.1432-1033.1997.00625.X
Jordi Muntane, Regulation of drug metabolism and transporters. Current Drug Metabolism. ,vol. 10, pp. 932- 945 ,(2009) , 10.2174/138920009790274595
Jukka Hakkola, Olavi Pelkonen, Markku Pasanen, Hannu Raunio, Xenobiotic-Metabolizing Cytochrome P450 Enzymes in the Human Feto-Placental Unit: Role in Intrauterine Toxicity Critical Reviews in Toxicology. ,vol. 28, pp. 35- 72 ,(1998) , 10.1080/10408449891344173
Ronald N. Hines, D. Gail McCarver, The Ontogeny of Human Drug-Metabolizing Enzymes: Phase I Oxidative Enzymes Journal of Pharmacology and Experimental Therapeutics. ,vol. 300, pp. 355- 360 ,(2002) , 10.1124/JPET.300.2.355