Polymorphisms and haplotypes in the Interleukin-4 gene are associated with chronic periodontitis in a Brazilian population.
作者： Giovana Anovazzi , Yeon J Kim , Aline C Viana , Karen MC Curtis , Silvana RP Orrico
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摘要: Background: Some haplotypes in the interleukin-4 (IL4) gene were reported to influence IL-4 cytokine production and associated with inflammatory diseases. Association studies focusing on IL4 polymorphisms periodontal disease provided conflicting results. The aim of this study is investigate whether related chronic periodontitis a Brazilian population.Methods: –590(C/T) +33(C/T) identified by polymerase chain reaction (PCR) restriction fragment-length polymorphism methods; variable number tandem repeats (VNTR) was PCR. To assess differences between group (n = 125) control 125), χ2 test used genotype allele distributions individual polymorphisms. For reconstructed an expectation-maximization algorithm, CLUMP program Fisher exact used. Multivariate logistic regression modeling use...
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