The epidermal growth factor receptor responsive miR-125a represses mesenchymal morphology in ovarian cancer cells.
作者： Karen D. Cowden Dahl , Richard Dahl , Jessica N. Kruichak , Laurie G. Hudson
DOI: 10.1593/NEO.09942
关键词:
摘要: The epithelial-to-mesenchymal transition (EMT) that occurs during embryonic development is recapitulated tumor metastasis. Important regulators of this process include growth factors, transcription and adhesion molecules. New evidence suggests microRNA (miRNA) activity contributes to metastatic progression EMT; however, the mechanisms leading altered miRNA expression cancer remain poorly understood. Importantly, overexpression epidermal factor receptor (EGFR) in ovarian correlates with poor disease outcome induces EMT cells. We report EGFR signaling leads transcriptional repression miR-125a through ETS family PEA3. Overexpression conversion highly invasive cells from a mesenchymal an epithelial morphology, suggesting negative regulator EMT. identify AT-rich interactive domain 3B (ARID3B) as target demonstrate ARID3B overexpressed human cancer. Repression represents novel mechanism for regulating behavior.
core.ac.uk
sci-hub.se 参考文章(23)
Navneet Sangha, Rong Wu, Rork Kuick, Scott Powers, David Mu, Diane Fiander, Kit Yuen, Hidetaka Katabuchi, Hironori Tashiro, Eric R. Fearon, Kathleen R. Cho, Neurofibromin 1 (NF1) Defects Are Common in Human Ovarian Serous Carcinomas and Co-occur with TP53 Mutations Neoplasia. ,vol. 10, pp. 1362- 1372 ,(2008) , 10.1593/NEO.08784
Quanwen Li, Raymond R. Mattingly, Restoration of E-cadherin Cell-Cell Junctions Requires Both Expression of E-cadherin and Suppression of ERK MAP Kinase Activation in Ras-Transformed Breast Epithelial Cells Neoplasia. ,vol. 10, pp. 1444- 1458 ,(2008) , 10.1593/NEO.08968
Shawn M. Ellerbroek, Janel K. Warmka, Elizabeth V Wattenberg, M. Sharon Stack, Mario Benavidez, Jennifer M. Halbleib, Laurie G. Hudson, Laurie G. Hudson, Phosphatidylinositol 3-kinase activity in epidermal growth factor-stimulated matrix metalloproteinase-9 production and cell surface association. Cancer Research. ,vol. 61, pp. 1855- 1861 ,(2001)
G Scambia, P Benedetti Panici, F Battaglia, G Ferrandina, G Baiocchi, S Greggi, R De Vincenzo, S Mancuso, Significance of epidermal growth factor receptor in advanced ovarian cancer. Journal of Clinical Oncology. ,vol. 10, pp. 529- 535 ,(1992) , 10.1200/JCO.1992.10.4.529
Philip A. Gregory, Andrew G. Bert, Emily L. Paterson, Simon C. Barry, Anna Tsykin, Gelareh Farshid, Mathew A. Vadas, Yeesim Khew-Goodall, Gregory J. Goodall, The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 Nature Cell Biology. ,vol. 10, pp. 593- 601 ,(2008) , 10.1038/NCB1722
Els M. J. J. Berns, Jan G. M. Klijn, Sonja C. Henzen-Logmans, Cees J. Rodenburg, Maria E. L. van der Burg, John A. Foekens, Receptors for hormones and growth factors and (onco)-gene amplification in human ovarian cancer International Journal of Cancer. ,vol. 52, pp. 218- 224 ,(1992) , 10.1002/IJC.2910520211
Margit A Huber, Norbert Kraut, Hartmut Beug, Molecular requirements for epithelial-mesenchymal transition during tumor progression. Current Opinion in Cell Biology. ,vol. 17, pp. 548- 558 ,(2005) , 10.1016/J.CEB.2005.08.001
C. J. R. Stewart, O. J. Owens, J. A. Richmond, A. M. McNicol, Expression of epidermal growth factor receptor in normal ovary and in ovarian tumors. International Journal of Gynecological Pathology. ,vol. 11, pp. 266- 272 ,(1992) , 10.1097/00004347-199210000-00004
Reema Zeineldin, Martina Rosenberg, Dominic Ortega, Christian Buhr, Miquella G. Chavez, M. Sharon Stack, Donna F. Kusewitt, Laurie G. Hudson, Mesenchymal transformation in epithelial ovarian tumor cells expressing epidermal growth factor receptor variant III. Molecular Carcinogenesis. ,vol. 45, pp. 851- 860 ,(2006) , 10.1002/MC.20237
Xin Li, Richard W. Carthew, A microRNA Mediates EGF Receptor Signaling and Promotes Photoreceptor Differentiation in the Drosophila Eye Cell. ,vol. 123, pp. 1267- 1277 ,(2005) , 10.1016/J.CELL.2005.10.040