Comparison of 25-hydroxy vitamin D3, adiponectin and apolipoproteinA5 levels in subjects with different glucose tolerance and their correlationwith blood lipid.
作者： Yong-Hui Yan , Fu-Rong Li , Qi Huang , Yan Yang , Han Zhang
DOI:
关键词:
摘要: This study aims to compare 25-hydroxy vitamin D3 (25(OH)D3), adiponectin (ADPN) and apolipoprotein A5 (apoA5) levels among subjects with different glucose tolerance explore their correlation lipid metabolism. Subjects were divided into 98 cases of type 2 diabetes mellitus (T2DM group), 87 impaired regulation (IGR group) 100 normal (NGT group). 25(OH)D3, (ADPN), (apoA5), hemoglobin A1c (HbA1c) blood estimated analyzed. It was found that the ADPN, apoA5 high-density lipoprotein cholesterol (HDL-C) in T2DM IGR groups lower than NGT group, while HbA1c, total (TC), triacylglycerol (TG) LDL-C higher group (P<0.05). Levels HDL-C group. However, TC, TG Therefore, low plasma ADPN may possibly be risk factors for tolerance, thus concentrations could important prevention dyslipidemia T2DM.
abacademies.org参考文章(17)
Ahmet Cimbek, Zuhal Kiliç, Gül Gürsoy, Fatih Güngör, Yaşar Acar, Nazli Gülsoy Kirnap, Işil Ozaşik, Relation of obesity with serum 25 hydroxy vitamin D3 levels in type 2 diabetic patients. Journal of Research in Medical Sciences. ,vol. 17, pp. 1119- 1123 ,(2012)
Boudewijn Klop, Jan Elte, Manuel Cabezas, Dyslipidemia in Obesity: Mechanisms and Potential Targets Nutrients. ,vol. 5, pp. 1218- 1240 ,(2013) , 10.3390/NU5041218
A. Norman, J. Frankel, A. Heldt, G. Grodsky, Vitamin D deficiency inhibits pancreatic secretion of insulin Science. ,vol. 209, pp. 823- 825 ,(1980) , 10.1126/SCIENCE.6250216
Young-Ah Moon, Guosheng Liang, Xuefen Xie, Maria Frank-Kamenetsky, Kevin Fitzgerald, Victor Koteliansky, Michael S. Brown, Joseph L. Goldstein, Jay D. Horton, The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals. Cell Metabolism. ,vol. 15, pp. 240- 246 ,(2012) , 10.1016/J.CMET.2011.12.017
Ifigenia Kostoglou-Athanassiou, Panagiotis Athanassiou, Anastasios Gkountouvas, Philippos Kaldrymides, Vitamin D and glycemic control in diabetes mellitus type 2 Therapeutic Advances in Endocrinology and Metabolism. ,vol. 4, pp. 122- 128 ,(2013) , 10.1177/2042018813501189
Dhia J Al-Timimi, Ardawan F Ali, Serum 25(OH) D in Diabetes Mellitus Type 2: Relation to Glycaemic Control. Journal of clinical and diagnostic research : JCDR. ,vol. 7, pp. 2686- 2688 ,(2013) , 10.7860/JCDR/2013/6712.3733
S. Simsek, Y.H.M. Poel, P. Hummel, P. Lips, F. Stam, T. van der Ploeg, Vitamin D and gestational diabetes: A systematic review and meta-analysis European Journal of Internal Medicine. ,vol. 23, pp. 465- 469 ,(2012) , 10.1016/J.EJIM.2012.01.007
SFC Vaessen, GM Dallinga-Thie, CJD Ross, LJ Splint, LW Castellani, PCN Rensen, MR Hayden, FG Schaap, JA Kuivenhoven, None, Plasma apolipoprotein AV levels in mice are positively associated with plasma triglyceride levels. Journal of Lipid Research. ,vol. 50, pp. 880- 884 ,(2009) , 10.1194/JLR.M800551-JLR200
Benjamin U. Nwosu, Zheni G. Stavre, Louise Maranda, Karen Cullen, Mary M. Lee, Hepatic dysfunction is associated with vitamin D deficiency and poor glycemic control in diabetes mellitus. Journal of Pediatric Endocrinology and Metabolism. ,vol. 25, pp. 181- 186 ,(2012) , 10.1515/JPEM-2011-0403
Holly Kirby, Michael D Feher, Mark Greener, Neil M Munro, Persistent hypertriglyceridemia in statin-treated patients with type 2 diabetes mellitus Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. ,vol. 6, pp. 11- 15 ,(2013) , 10.2147/DMSO.S35053