The Potential Role of Trained Immunity in Autoimmune and Autoinflammatory Disorders.

摘要: During induction of trained immunity, monocytes and macrophages undergo a functional transcriptional reprogramming toward increased activation. Important rewiring cellular metabolism the myeloid cells takes place during including shift glycolysis induced through mTOR pathway, as well glutaminolysis cholesterol synthesis. Subsequently, this leads to modulation function epigenetic enzymes, resulting in important changes chromatin architecture that enables gene transcription. However, addition beneficial effects immunity host defense mechanism, we hypothesize also plays deleterious role and/or maintenance autoimmune autoinflammatory diseases if inappropriately activated.