Potassium usnate toxicity against embryonic stages of the snail Biomphalaria glabrata and Schistosoma mansoni cercariae.

摘要: Abstract The snail Biomphalaria glabrata is the most important vector for Schistosoma mansoni. Control of this to prevent spread schistosomiasis currently performed with application a niclosamide molluscicide, which highly toxic environment. Screening substances that show embryotoxic molluscicidal potential as well have detrimental effects on cercariae very relevant control schistosomiasis, efficacy prevention disease increased if it acts molluscicide S. aim work was evaluate effect potassium usnate derived from usnic acid different stages embryonic development B. and mansoni cercariae. After 24 h exposure, showed activity across all stages. values obtained LC50 were following: blastula 5.22 μg/mL, gastrula 3.21 μg/mL, trochophore 3.58 μg/mL, veliger 2.79, hippo stage 2.52 μg/mL. Against cercariae, had LC90 100% mortality at concentrations 2.5 5 μg/mL in 2 h exposure. In conclusion, first report toxicity mansoni, study shows promising agent schistosomiasis.