High-level iodination of monoclonal antibody fragments for radiotherapy.

作者: Jorge A. Carrasquillo , Ingegerd Hellström , Karl Erik Hellström , Paul L. Beaumier , Kenneth A. Krohn

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摘要: Two different murine monoclonal antibody Fab fragments specific for p97, a melanoma-associated antigen, were labeled with I-131 at high activity levels without excessive chemical damage. Up to 20 mg of up 300 mCi using the chloramine-T method and large working volumes room temperature. As much as 90% initial was recovered product. The Fabs varied in their sensitivity radioiodination damage, measured by an vitro cell-binding assay. Radioiodination performed safely remote iodination apparatus. final product radiopharmaceutical quality suitable clinical diagnosis experimental radiotherapy humans.

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