Characterization of Rhinitis According to the Asthma Status in Adults Using an Unsupervised Approach in the EGEA Study

摘要: Background The classification of rhinitis in adults is missing epidemiological studies. Objective To identify phenotypes adult using an unsupervised approach (data-driven) compared with a classical hypothesis-driven approach. Methods 983 the French Epidemiological Study on Genetics and Environment Asthma (EGEA) were studied. Self-reported symptoms related to such as nasal symptoms, hay fever, sinusitis, conjunctivitis, sensitivities different triggers (dust, animals, hay/flowers, cold air…) used. Allergic sensitization was defined by at least one positive skin prick test 12 aeroallergens. Mixture model used cluster participants, independently those without (Asthma-, n = 582) asthma (Asthma+, 401). Results Three clusters identified both groups: 1) Cluster A (55% Asthma-, 22% Asthma+) mainly characterized absence 2) B (23% 36% all over year, sinusitis low prevalence tests, 3) C (22% 42% peak during spring, high tests report allergic conjunctivitis. The highest rate polysensitization (80%) found participants comorbid rhinitis. Conclusion This analysis highlighted three similar characteristics than known clinicians but differing according sensitization, this whatever status. These could be easily rebuilt small number variables.