Pathology

摘要: For over 140 years, pathological studies of human and animal material have continued to provide important insights towards a better understanding the complex pathogenesis rabies. As highly neurotropic infection central nervous system, rabies shares spectrum histopathological changes with other viral encephalitides, including leptomeningeal perivascular mononuclear inflammatory cell infiltrates, microglial activation, neuronophagia. The presence Negri bodies, eosinophilic inclusions in cytoplasm infected neurons, is unique pathognomonic finding many cases ‘street’ virus infection. Although naturally occurring almost invariably lethal, neuronal death are minimal some cases. Data from experimental models suggest that structural processes, vacuolation presynaptic nerve endings, may be sufficient account for fatal outcome Neuronal apoptosis does not play an pathogenetic role encephalitis. Immunohistochemical antigen distribution humans animals been particularly elucidating pathogenesis, centripetal centrifugal spread through peripheral system involvement extraneural organs, salivary glands heart.