A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers

摘要: Aberrant soluble oligomers formed by the amyloid-β peptide (Aβ) are major pathogenic agents in onset and progression of Alzheimer's disease. A variety biomolecules can influence formation these brain, although their mechanisms action still largely unknown. Here, we studied effects on Aβ aggregation DOPAL, a reactive catecholaldehyde intermediate dopamine metabolism. We found that DOPAL is able to stabilize oligomeric species, including dimers trimers, exert toxic human neuroblastoma cells, particular increasing cytosolic calcium levels promoting generation oxygen species. These results reveal an interplay between key biochemical processes regulating cellular homeostasis brain.