Diverting autophagic membranes for exocytosis

摘要: We have recently shown that the Epstein Barr virus (EBV) incorporates autophagic membrane label LC3B-II into mature particles. Upon EBV production, membranes are stabilized and infectious viral particle production is dependent on these, because ATG protein-deficiency dampens, whereas rapamycin induces, production. Moreover, DNA accumulates in cytosol when macroautophagy impaired. therefore conclude needs for efficient enveloping during Here, we discuss how might incorporate lipidated LC3B (LC3B-II) envelope other viruses as well cellular processes customize machinery exocytosis context of unconventional secretion.