Performance evaluation of bipolar and tripolar excitations during nozzle-jetting-based alginate microsphere fabrication

摘要: Microspheres, small spherical (polymeric) particles with or without second phase materials embedded encapsulated, are important for many biomedical applications such as drug delivery and organ printing. Scale-up fabrication the ability to precisely control microsphere size morphology has always been of great manufacturing interest. The objective this work is experimentally study performance differences bipolar tripolar excitation waveforms in using drop-on-demand (DOD)-based single nozzle jetting alginate fabrication. evaluated based on formability microspheres a function properties (sodium calcium chloride concentrations) operating conditions. conditions each include voltage rise/fall times, dwell times amplitudes. Overall, more robust making spherical, monodispersed good its wide working range material conditions, especially during highly viscous 2% sodium solution. For both excitations, concentration should be carefully selected achieve formability.