Recombinant monovalent antibodies and methods for production thereof
作者： Paul Parren , Willem Karel Bleeker , Frank Beurskens , Tom Vink , Jan G.J. Van De Winkel
DOI:
关键词:
摘要: The present invention provides monovalent antibodies with a long half-life when administered in vivo, methods of making such antibodies, pharmaceutical compositions comprising and uses the antibodies.
google.ba 参考文章(125)
I Sakurabayashi, K Kin, T Kawai, Human IgA1 Half-Molecules: Clinical and Immunologic Features in a Patient With Multiple Myeloma Blood. ,vol. 53, pp. 269- 278 ,(1979) , 10.1182/BLOOD.V53.2.269.269
AD D'Andrea, BJ Rup, MJ Fisher, S Jones, Anti-Erythropoietin Receptor (EPO-R) Monoclonal Antibodies Inhibit Erythropoietin Binding and Neutralize Bioactivity Blood. ,vol. 82, pp. 46- 52 ,(1993) , 10.1182/BLOOD.V82.1.46.BLOODJOURNAL82146
HL Spiegelberg, VC Heath, JE Lang, IgG half-molecules: clinical and immunologic features in a patient with plasma cell leukemia Blood. ,vol. 45, pp. 305- 313 ,(1975) , 10.1182/BLOOD.V45.3.305.305
Mihaesco E, Chevalier A, Seligmann M, Miglierina R, Immunochemical study of a human myeloma IgG1 half molecule. Annales De L'institut Pasteur. Immunologie. pp. 855- ,(1978)
A T Worth, K S Kan, V A Anderson, G T Stevenson, Conjugation of human Fc gamma in closed-hinge or open-hinge configuration to Fab'gamma and analogous ligands. Journal of Immunology. ,vol. 158, pp. 2242- 2250 ,(1997)
H Waldmann, M Clark, G Hale, Therapeutic potential of rat monoclonal antibodies: isotype specificity of antibody-dependent cell-mediated cytotoxicity with human lymphocytes. Journal of Immunology. ,vol. 134, pp. 3056- 3061 ,(1985)
C Horgan, K Brown, S H Pincus, Studies on antigen binding by intact and hinge-deleted chimeric antibodies. Journal of Immunology. ,vol. 150, pp. 5400- 5407 ,(1993)
F D Finkelman, S C Morris, K B Madden, I M Katona, J M Holmes, N Boiani, C R Maliszewski, Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes. Journal of Immunology. ,vol. 151, pp. 1235- 1244 ,(1993)
Eduardo A. Padlan, Chantal Abergel, Jennifer P. Tipper, Identification of specificity-determining residues in antibodies. The FASEB Journal. ,vol. 9, pp. 133- 139 ,(1995) , 10.1096/FASEBJ.9.1.7821752
John L. Fahey, Stewart Sell, Relationship Between γ-Globulin Metabolism and Low Serum γ-Globulin in Germfree Mice Journal of Immunology. ,vol. 93, pp. 81- 87 ,(1964)