Multiple Sclerosis That Is Progressive From the Time of Onset: Clinical Characteristics and Progression of Disability

摘要: Objective: To use the new consensus definitions of primary progressive multiple sclerosis (PPMS) and relapsing (PRMS) to report demographic, clinical, natural history characteristics (MS) that is from time onset. Design: Retrospective study by database/chart review telephone interview. Setting: Multiple clinic at a university teaching hospital. Patients: Eighty-three patients (prevalence, 6.9%) with PPMS 12 1.0%) PRMS were studied. Results: Fifty-nine percent (n = 49) 67% 8) women. Mean ± SD ages onset 41.2 10.5 38.0 7.3 years, respectively; mean disease duration was 14.2 8.8 12.2 6.5 respectively. The initial symptoms involved leg weakness in 94% 78) 100% 12). For cohort, syndrome consistent isolated myelopathy found 36% 30) arm without did not occur. SEM progression score 6.0 on Expanded Disability Status Scale 10.2 1.0 years for 10.9 2.6 PRMS. Conclusions: clinical disability these MS subtypes indistinguishable, exception 1 or 2 relapses occurred 8 months 9 after symptoms. We see little reason consider separate entities; however, whether they can be better distinguished radiological, histopathological, immunological markers activity remains unknown. Arch Neurol. 1999;56:1138-1142