Metformin suppresses intrahepatic coagulation activation in mice with lipopolysaccharide/D‑galactosamine‑induced fulminant hepatitis

摘要: Metformin is a widely‑used antidiabetic drug with hypoglycemic activity and previously described anti‑inflammatory properties. Previous studies have demonstrated that metformin attenuates endotoxic hepatitis, however the mechanisms remain unclear. Inflammation coagulation are closely associated pathological processes, therefore potential effects of on key steps in activation system were further investigated hepatitis induced by lipopolysaccharide/D‑galactosamine (LPS/D‑Gal). The current study treatment significantly suppressed upregulation tissue factor plasminogen activator inhibitor‑1 LPS/D‑Gal‑exposed mice. In addition, reduction expression interleukin 6 inhibition nuclear translocation factor‑κB observed. These data indicate LPS/D‑Gal‑induced elevation stable protein level hypoxia inducible 1α, mRNA erythropoietin, vascular endothelial growth matrix metalloproteinase‑3, hepatic lactic acid also metformin. indicates suppressive inflammation‑induced may be an additional mechanism underlying hepatoprotective mice fulminant hepatitis.