Interference of Pb with essential brain tissue Cu, Fe, and Zn as main determinant in experimental tetraethyllead encephalopathy

摘要: Abstract After exposure of rabbits to tetraethyllead, each analyzed brain area (frontal cortex, cerebellum, hippocampus) contained approximately 33 μg lead per gram dry weight. At the same time, there was a statistically significant loss in areas essential elements, copper, iron, and zinc. While molar ratio between gain decrease copper revealed an approximate proportionality 1:1, iron 1:2. The zinc levels varied these lowest inferior hippocampus. potentiality interference with trace metals brain, preferentially metal group metalloenzymes, as primary dominant mechanism toxic action encephalopathy, is discussed.