Dietary Factors and the Risk of Incident Kidney Stones in Younger Women

摘要: Background In older women and men, greater intakes of dietary calcium, potassium, total fluid reduce the risk kidney stone formation, while supplemental sodium, animal protein, sucrose may increase risk. Recently, phytate has been suggested to play a role in formation. To our knowledge, no prospective information on factors formation is available younger women. Methods We prospectively examined, during an 8-year period, association between incident symptomatic stones among 96 245 female participants Nurses' Health Study II; were aged 27 44 years had history stones. Self-administered food frequency questionnaires used assess diet 1991 1995. The main outcome measure was stone. Cox proportional hazards regression models adjust simultaneously for various factors. Results documented 1223 685 973 person-years follow-up. After adjusting relevant factors, higher calcium intake associated with reduced (P =.007 trend). multivariate relative highest quintile compared lowest 0.73 (95% confidence interval, 0.59-0.90). Supplemental not Phytate Compared intake, those 0.63 0.51-0.78). Other showed following risks intervals) quintile: 0.84 (0.68-1.04); fluid, 0.68 (0.56-0.83); sucrose, 1.31 (1.07-1.60). magnesium independently after other Conclusions A decreases women, but This study also suggests that some differ by age sex. Finally, be new, important, safe addition options prevention.