Effectiveness of a 10-Day Melarsoprol Schedule for the Treatment of Late-Stage Human African Trypanosomiasis: Confirmation from a Multinational Study (Impamel II)

摘要: Background. Treatment of late-stage human African trypanosomiasis (HAT) with melarsoprol can be improved by shortening the regimen. A previous trial demonstrated safety and efficacy a 10-day treatment schedule. We demonstrate effectiveness this schedule in noncontrolled, multinational drug-utilization study. Methods. total 2020 patients HAT were treated 16 centers 7 countries. assessed outcome on basis major adverse events cure rate after during 2 years follow-up. Results. The 24 h was 93.9%; later, it 86.2%. However, 49.3% lost to overall fatality 5.9%. Of patients, 8.7% had an encephalopathic syndrome that fatal 45.5% time. severe bullous maculopapular eruptions 0.8% 6.8%, respectively. Conclusions. well implemented field effective. It reduces duration, drug amount, hospitalization costs per patient, increases treatment-center capacity. shorter protocol has been recommended International Scientific Council for Trypanosomiasis Research Control caused Trypanosoma brucei gambiense.