Cullin 3 as a novel target in diverse pathologies

摘要: Recent evidence suggests that the malfunctioning disposal system of cell protein called ubiquitin-proteasome (UPS) plays an important role in development disorders, including cancer and neurodegenerative diseases. Accumulating abnormal regulation E3 ubiquitin ligases, essential components UPS, contributes to uncontrolled proliferation, genomic instability cancer, since these ligases their substrates are involved cycle progression, gene transcription, signal transduction, DNA replication others. Through selective degradation specific substrates, regulate different biological processes. Cullins a family proteins confer substrate specificity multimeric complex acting as scaffold proteins. So far, seven members cullin have been identified. Interestingly, data generated by several groups indicate 3 (Cul3) has begun emerge etiopathology multiple In this paper we examine latest advances basic research on biology Cul3 how it could help direct drug discovery efforts target.