Surface induced collapse of Aβ1-42 with the F19A replacement following adsorption on a single walled carbon nanotube.

摘要: Spontaneous adsorption of the Aβ peptide on surface a single-walled carbon nanotube, resulting in prevention its intrinsic propensity to form collapsed states, could be plausible means hinder peptide's initial nucleation and self-assembly. We report here effects sharply reducing both aromatic hydrophobic character within central core free behavior. In such an altered peptide, complete is found induce, rather than prevent, adsorbed collapse. The weakened interactions allow greater translational mobility surface, thereby facilitating that lead compaction. Both subsequent collapse are accompanied by loss hydration modified peptide. further find two-step dewetting leads levels comparable obtained after compaction These insights may leveraged for designing molecular surfaces disrupting