2.208 – Artificial Extracellular Matrices to Functionalize Biomaterial Surfaces

摘要: The extracellular matrix (ECM) is a determining factor of cell fate, and for this reason the utilization ECM components to construct bioactive scaffolds coatings has become focus interest. naturally occurring offers multitude with very diverse functions, topic chapter artificial (aECM) constructed select view eliciting specific responses in cells tissues. In majority cases, collagen basic material, which can be modified using number different glycoproteins, proteoglycans, glycosaminoglycans, giving rise aECM morphological biochemical characteristics that affect behavior ultimately tissue response. chapter, these are described their numerous interactions each other, soluble such as growth factors cytokines, cellular receptors. Preparation immobilization methods consequences structure discussed next, final sections summarize animal experimental data aECM, illustrating potential matrices direct fate.