MicroRNA Technology and Small-Molecule Delivery

作者: Theresa A. Lusardi , Detlev Boison

DOI: 10.1016/B978-0-12-405544-5.00037-X

关键词:

摘要: Abstract Homeostasis of the body’s small molecules is significant in health and disease. Homeostatic functions are part regulated by microRNAs (miRNAs). In regenerative medicine, therapeutic miRNAs may be ideally suited to restoring network homeostasis molecules, such as adenosine or glucose, this way affecting entire regulatory networks on a more holistic level. Therapeutic can introduced via ex vivo gene therapies, illustrated here for adenosine, directly an interesting area that should explored future applications. This chapter discusses miRNA-based experimental approaches harness potential molecules.

参考文章(67)
Marc Fatar, Mark Stroick, Martin Griebe, Irma Marwedel, Susanne Kern, Karen Bieback, Frederik L. Giesel, Christian Zechmann, Stefan Kreisel, Frederike Vollmar, Angelika Alonso, Walter Back, Stephen Meairs, Michael G. Hennerici, Lipoaspirate-derived adult mesenchymal stem cells improve functional outcome during intracerebral hemorrhage by proliferation of endogenous progenitor cells stem cells in intracerebral hemorrhages. Neuroscience Letters. ,vol. 443, pp. 174- 178 ,(2008) , 10.1016/J.NEULET.2008.07.077
Bjorn-Erik Wulff, Kazuko Nishikura, Modulation of MicroRNA Expression and Function by ADARs Current Topics in Microbiology and Immunology. ,vol. 353, pp. 91- 109 ,(2011) , 10.1007/82_2011_151
Roopali Gandhi, Brian Healy, Taha Gholipour, Svetlana Egorova, Alexander Musallam, Mohammad Shuja Hussain, Parham Nejad, Bonny Patel, Hillary Hei, Samia Khoury, Francisco Quintana, Pia Kivisakk, Tanuja Chitnis, Howard L. Weiner, Circulating microRNAs as biomarkers for disease staging in multiple sclerosis. Annals of Neurology. ,vol. 73, pp. 729- 740 ,(2013) , 10.1002/ANA.23880
Beverly L. Davidson, Paul B. McCray, Current prospects for RNA interference-based therapies Nature Reviews Genetics. ,vol. 12, pp. 329- 340 ,(2011) , 10.1038/NRG2968
Karl J.L. Fernandes, Nao R. Kobayashi, Conor J. Gallagher, Fanie Barnabé-Heider, Anne Aumont, David R. Kaplan, Freda D. Miller, Analysis of the neurogenic potential of multipotent skin-derived precursors Experimental Neurology. ,vol. 201, pp. 32- 48 ,(2006) , 10.1016/J.EXPNEUROL.2006.03.018
Kon Chu, Manho Kim, Sang-Wuk Jeong, Seung U Kim, Byung-Woo Yoon, None, Human neural stem cells can migrate, differentiate, and integrate after intravenous transplantation in adult rats with transient forebrain ischemia. Neuroscience Letters. ,vol. 343, pp. 129- 133 ,(2003) , 10.1016/S0304-3940(03)00174-5
Kon Chu, Manho Kim, Keun-Hwa Jung, Daejong Jeon, Soon-Tae Lee, Juhyun Kim, Sang-Wuk Jeong, Seung Up Kim, Sang Kun Lee, Hee-Sup Shin, Jae-Kyu Roh, None, Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpine-induced status epilepticus in adult rats. Brain Research. ,vol. 1023, pp. 213- 221 ,(2004) , 10.1016/J.BRAINRES.2004.07.045
Kristy R. Kutanzi, Olga V. Yurchenko, Frederick A. Beland, Vasyl’ F. Checkhun, Igor P. Pogribny, MicroRNA-mediated drug resistance in breast cancer Clinical Epigenetics. ,vol. 2, pp. 171- 185 ,(2011) , 10.1007/S13148-011-0040-8
J Ma, C Dong, C Ji, MicroRNA and drug resistance. Cancer Gene Therapy. ,vol. 17, pp. 523- 531 ,(2010) , 10.1038/CGT.2010.18
K. A. Jackson, T. Mi, M. A. Goodell, Hematopoietic potential of stem cells isolated from murine skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 14482- 14486 ,(1999) , 10.1073/PNAS.96.25.14482