作者: Giovanni Corrao , Vincenzo Bagnardi , Antonella Zambon , Sarino Arico
DOI: 10.1046/J.1360-0443.1999.9410155111.X
关键词:
摘要: Objective. To compare the strength of evidence provided by epidemiological literature on association between alcohol consumption and risk six cancers (oral cavity, oesophagus, colorectum, liver, larynx, breast), hypertension, cerebrovascular diseases, gastric duodenal ulcer, liver cirrhosis other chronic pancreatitis injures adverse effects. Methods. A search from 1966 to 1998 was performed several bibliographic databases. Metaregression models were fitted considering fixed random linear non-linear effects intake each condition. The some characteristics studies including an index their quality considered as putative sources heterogeneity estimates. Publication bias also investigated asymmetry funnel plots. Results. Of 397 initially reviewed studies, 200 selected for meta-analysis. Since qualitative often significant among them, estimates pooled dose-response slopes based only 123 with higher score and/or reporting adjusted relative risks. Higher alcohol-related risks found cirrhosis, neoplasms upper respiratory digestive tracts, haemorrhagic stroke injuries Weaker but associations breast cancers, essential hypertension pancreatitis. For all these conditions, low intakes, corresponding daily two drinks or glasses wine (25 g/day), have shown Ischaemic ulcer seem independent intake. area in which study performed, study's design outcome variable differently affected slopes. Conclusions. small number sufficiently reliable strong indications across them suspicion publication suggest that there is a great need well-conducted countries, examine relationship well role drinking pattern determining risk.