TGFβ and BMP signaling in cardiac cushion formation: lessons from mice and chicken.
作者： Boudewijn P.T. Kruithof , Sjoerd N. Duim , Asja T. Moerkamp , Marie-José Goumans
DOI: 10.1016/J.DIFF.2012.04.003
关键词:
摘要: Cardiac cushion formation is crucial for both valvular and septal development. Disruption in this process can lead to malformations, which constitute the largest part of congenital heart defects. One signaling pathways that important TGFβ superfamily. The involvement BMP cardiac has been intensively studied using chicken vitro explant assays genetically modified mice. In review, we will summarize discuss role components formation.
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