Novel substrates for, and sources of, progestogens for reproduction.
作者： Cheryl Anne Frye
DOI: 10.1111/J.1365-2826.2011.02180.X
关键词:
摘要: Steroid hormones, such as progesterone (P), are typically thought of being primarily secreted by the gonads (albeit adrenals can also be a source) and having their actions through cognate intracellular progestin receptors (PRs). Through its in midbrain Ventral Tegmental Area (VTA), P mediates appetitive (exploratory, anxiety, social approach) consummatory (social, sexual) aspects rodents’ mating behavior (Frye et al., 2006a). However, natural metabolites (“progestogens”) produced VTA independent peripheral sources adult rodents is devoid PRs. One approach we have used to understand P’s effects mechanisms for manipulate examine on lordosis (the posture female assume occur). This review focuses progestogens influence reproduction related proce sses. Actions 5α-reduced metabolite neurosteroid, 5α-pregnan-3α-ol-20-one (3α,5α-THP; allopregnanolone) facilitate described. The findings that 3α,5α-THP biosynthesis occurs with discussed. Evidence 3α,5α-THP’s via non-traditional steroid targets summarised. broader relevance these 3α,5α-THP, reproduction, beyond lordosis, Finally, potential role pregnane xenobiotic receptor mediating introduced.
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