Randomized controlled trial of calcium in healthy older women.

摘要: Abstract Purpose Calcium has been shown to have positive effects on bone mineral density in postmenopausal women. However, these are small, it is unknown whether they sustained with long-term use, not intention-to-treat analyses, and the evidence for fracture prevention calcium monotherapy inconsistent. Methods A randomized controlled trial of (1 g/day as citrate) 1471 healthy women (aged 74±4 years) was performed assess incidence over 5 years. Results Follow-up complete 90% subjects, average medication compliance 55% 58%. had a significant beneficial effect (intention-to-treat analysis), between-groups differences at years 1.8% (spine), 1.6% (total hip), 1.2% body). Effects were greater per-protocol analysis (5-year 2.3%, 2.8%, 1.8%, respectively). total 425 fractures occurred 281 Hazard ratios, based time first fracture, 0.90 (95% confidence interval [CI], 0.71-1.16) any symptomatic 0.72 CI, 0.44-1.18) vertebral, 3.55 1.31-9.63) hip, 0.65 0.41-1.04) forearm fracture. Per-protocol found respective hazard ratios 0.86 0.64-1.17), 0.62 0.33-1.16), 3.24 0.65-16.1), 0.45 0.24-0.87). Height loss reduced by population ( P =.03). Serum alkaline phosphatase procollagen type-I N-terminal propeptide lower group years, but constipation more common. Conclusions results reduction turnover, its remains uncertain. Poor limits effectiveness.