Candidate gene polymorphisms in eating disorders

摘要: Anorexia nervosa and bulimia are complex disorders characterized by disordered eating behaviour. Attitudes towards weight shape as well the perception of body disturbed. A substantial genetic influence on these has been suggested formal studies. Obsessive-compulsive behaviour, perfectionism anxious personality traits seem to occur premorbidly in several patients. Disturbances neurotransmitter, neuropeptide neuroendocrine systems have reported acutely ill followed-up Hence, might be involved etiology disorders.Genetic studies candidate genes mainly focussed serotonergic system regulation. Up now, polymorphisms variations various (e.g. for 5-HT receptors, leptin gene, melanocortin MC(4) receptor gene) assessed association transmission disequilibrium pertaining anorexia and/or nervosa. Most yielded negative results. Four a polymorphism (-1438 G/A) within promoter 5-HT(2A) gene (5-HT(2A)) revealed an A-allele However, three could not confirm this result. Furthermore, meta-analysis did support positive association. Currently, combined efforts European Union will answer question whether or is predisposition test being performed about 300 trios consisting patient with both parents. As approaches unequivocally identify susceptibility (alleles) nervosa, systematic model-free genome-wide screenings should also order currently unknown disorders. This kind approach already initiated Genetic research hopefully lead new pharmacological treatment strategies.