In vivo measurement of gadolinium concentration in a rat glioma model by monochromatic quantitative computed tomography: comparison between gadopentetate dimeglumine and gadobutrol.
作者： G??raldine Le Duc , St??phanie Corde , Anne-Marie Charvet , H??l??ne Elleaume , R??gine Farion
DOI: 10.1097/01.RLI.0000124250.61768.C0
关键词:
摘要: Rationale and Objectives: Monochromatic quantitative computed tomography allows a nondestructive measurement of gadolinium (Gd) concentration. This technique was used in the C6 rat glioma model to comparegadopentetate dimeglumine gadobutrol. Methods: Rats bearing late-stage gliomas received 2.5 mmol/kg (392.5 mg Gd/kg) gadopentetate (n = 5) gadobutrol 6) intravenously before imaging session performed at European Synchrotron Radiation Facility. Results: enabled vivo follow-up Gd concentration as function time specified regions interest. Surprisingly, after injection, concentrations center periphery tumor were higher than those although identical normal contralateral area brain. Conclusion: The assessment absolute revealed differences behaviors tumoral tissues despite injections same conditions. These might be attributed different characteristics contrast agents.
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