Paclitaxel and Carboplatin, Alone or With Irradiation, in Advanced or Recurrent Endometrial Cancer: A Phase II Study

摘要: PURPOSE: To evaluate the efficacy of carboplatin plus paclitaxel in primarily advanced or recurrent endometrial cancers. PATIENTS AND METHODS: Four distinct patient groups received (area under curve, 5 to 7) 175 mg/m2 for 3 hours at 4-week intervals: group 1 (n = 21), patients with advanced, nonpapillary serous cancers; 2 20), same as but papillary 18), recurrent, and 4 4), Involved-field irradiation was used those radioencompassable disease. RESULTS: Sixty-three were treated. Response rates chemotherapy assessable four 78% (95% confidence interval [CI], 51% 100%); 60% CI, 35% 85%), 56% 34% 78%), 50%, respectively. Nineteen (90%) also irradiated, median failure-free survival time all 21 w...