Claustrum circuit components for top-down input processing and cortical broadcast.

摘要: Anterior cingulate cortex (ACC) input to the claustrum is required for top-down cognitive control of action. By virtue its widespread cortical connectivity, anatomically situated process and broadcast signals from ACC downstream cortices. To gain a deeper understanding processing mechanisms, it first critical identify projection neuron subtypes within claustrum, intrinsic extrinsic components regulating their firing, differential innervation by subtypes. this end, we used whole-cell patch-clamp electrophysiology in adult mouse brain slices distinguish two spiny referred as type I II neurons, three aspiny interneuron subtypes, III, IV, V neurons. In response optogenetic afferent stimulation, neurons preferentially burst fire relative This firing calcium-dependent optimized voltage-gated potassium channels. Finally, find that visual cortices, parietal association cortex, receive differing proportions. These data reveal diversity mechanisms which processes command spatiotemporal coordination cerebral cortex.;