Molecular targeted therapy for neuroendocrine tumors.

作者: James C. Yao , Paulo M. Hoff

DOI: 10.1016/J.HOC.2007.04.001

关键词:

摘要: Although endocrine tumors are often slow growing, most can be life threatening and considered resistant to conventional cytotoxic chemotherapy. The recent emergence of molecularly targeted therapy in oncology has brought renewed interest the development novel agents for this rare group diseases. Preliminary results from phase II studies have shown promising VEGF mTOR inhibitors carcinoid islet cell carcinoma RET medullary thyroid carcinoma. Large confirmatory planned.

参考文章(39)
Bonnie Kemp, Susan A. Silver, Kenneth Hurr, Adel K. El-Naggar, Microsatellite alteration at chromosome 3p loci in neuroendocrine and non-neuroendocrine lung tumors: Histogenetic and clinical relevance American Journal of Pathology. ,vol. 149, pp. 613- 620 ,(1996)
Daniele Lissandrini, Paolo Pederzoli, Giorgio Talamini, Edoardo Missiaglia, Aldo Scarpa, Giuseppe Zamboni, Massimo Falconi, Guido Rindi, Antonella Baron, Gildas Rigaud, Anna Pesci, Piergiovanni Grigolato, Patrick S. Moore, High Resolution Allelotype of Nonfunctional Pancreatic Endocrine Tumors: Identification of Two Molecular Subgroups with Clinical Implications Cancer Research. ,vol. 61, pp. 285- 292 ,(2001)
Götz von Wichert, Peter M. Jehle, Bernhard O. Boehm, Eckhard Wolf, Guido Adler, Henning Dralle, Andreas Hoeflich, Thomas Seufferlein, Bertram Wiedenmann, Stefan Koschnick, Insulin-like Growth Factor-I Is an Autocrine Regulator of Chromogranin A Secretion and Growth in Human Neuroendocrine Tumor Cells Cancer Research. ,vol. 60, pp. 4573- 4581 ,(2000)
Göran Åkerström, Carl-Henrik Heldin, Claes Juhlin, Jonas Rastad, Vasilis Papanicolaou, Kjell Öberg, Keiko Funa, Expression of Platelet-derived Growth Factor β-Receptors on Stromal Tissue Cells in Human Carcinoid Tumors Cancer Research. ,vol. 50, pp. 748- 753 ,(1990)
Dieter Marmé, Karin Weindel, Georg Martiny-Baron, Bernhard Barleon, Katja Mohrs, Gerhard Siemeister, Reversion of Deregulated Expression of Vascular Endothelial Growth Factor in Human Renal Carcinoma Cells by von Hippel-Lindau Tumor Suppressor Protein Cancer Research. ,vol. 56, pp. 2299- 2301 ,(1996)
Francesca Carlomagno, Teresa Guida, Suresh Anaganti, Giancarlo Vecchio, Alfredo Fusco, Anderson J Ryan, Marc Billaud, Massimo Santoro, Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors. Oncogene. ,vol. 23, pp. 6056- 6063 ,(2004) , 10.1038/SJ.ONC.1207810
Albert Kovatich, David M. Friedland, Teresa Druck, Piotr Hadaczek, Kay Huebner, Robert L. Comis, Walter Hauck, Peter A. McCue, Molecular alterations to human chromosome 3p loci in neuroendocrine lung tumors. Cancer. ,vol. 83, pp. 1109- 1117 ,(1998) , 10.1002/(SICI)1097-0142(19980915)83:6<1109::AID-CNCR9>3.0.CO;2-2
Aichi Yoshida, Shingo Hatanaka, Yasuyo Ohi, Yoshihisa Umekita, Hiroki Yoshida, Von Recklinghausen's Disease Associated with Somatostatin-rich Duodenal Carcinoid (Somatostatinoma), Medullary Thyroid Carcinoma and Diffuse Adrenal Medullary Hyperplasia Pathology International. ,vol. 41, pp. 847- 856 ,(1991) , 10.1111/J.1440-1827.1991.TB01629.X
Hiroyuki Konno, Tomio Arai, Tatsuo Tanaka, Megumi Baba, Keigo Matsumoto, Toshikazu Kanai, Satoshi Nakamura, Shozo Baba, Yasuhisa Naito, Haruhiko Sugimura, Ayako Yukita, Makoto Asano, Hideo Suzuki, Antitumor effect of a neutralizing antibody to vascular endothelial growth factor on liver metastasis of endocrine neoplasm Japanese Journal of Cancer Research. ,vol. 89, pp. 933- 939 ,(1998) , 10.1111/J.1349-7006.1998.TB00651.X
Christopher D.M. Fletcher, Heikki Joensuu, George D. Demetri, Margaret von Mehren, Charles D. Blanke, Annick D. Van den Abbeele, Burton Eisenberg, Peter J. Roberts, Michael C. Heinrich, David A. Tuveson, Samuel Singer, Milos Janicek, Jonathan A. Fletcher, Stuart G. Silverman, Sandra L. Silberman, Renaud Capdeville, Beate Kiese, Bin Peng, Sasa Dimitrijevic, Brian J. Druker, Christopher Corless, Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. The New England Journal of Medicine. ,vol. 347, pp. 472- 480 ,(2002) , 10.1056/NEJMOA020461