Synthetic modulators of TRP channel activity.

摘要: In humans, 27 TRP channels from 6 related families contribute to a broad spectrum of cellular functions, such as thermo-, pressure-, volume-, pain- and chemosensation. Pain inflammation-inducing compounds represent potent plant animal defense mechanisms explaining the great variety naturally occurring, TRPV1-, TRPM8-, TRPA1-activating ligands. The discovery first vanilloid receptor (TRPV1) its involvement in nociception triggered euphoria hope novel therapeutic strategies treating pain, this clear-cut indication inspired development TRPV1-selective On other hand nescience physiological role putative clinical hampered selective drug case channels. Therefore, currently only handful mostly un-selective blocker is available target Nevertheless, there an ongoing quest for new, natural or synthetic ligands modulators. chapter, we will give overview on broad-range blocker, well channel-selective compounds.