Pancreatic Cancer Surgery: The New R-status Counts.

摘要: Objective To assess the relevance of resection margin status for survival outcome after and adjuvant therapy pancreatic cancer. Background The definitions R0 R1 cancer are controversial. strict definition requiring a 1 mm tumor-free is not commonly accepted. Reported R0/R1 rates associated highly heterogeneous. Methods A standardized protocol with rigorous assessment circumferential margins free were introduced into clinical routine in 2005. From prospective database, patients undergoing pancreatoduodenectomy adenocarcinoma between January 1, 2006 December 12, 2012 identified. (≥1 margin), ( Results Of 561 included, 112 (20.0%) had 449 (80.0%) resections, including 123 (21.9%) (≤1 mm) 326 (58.1%) (direct) resections. total 438 (85.9%) received therapy. With R0, Conclusions In context therapy, remains an important independent determinant postresection survival. vary significantly used. An international consensus urgently needed to achieve comparability respect studies protocols on