Targeting G-quadruplex nucleic acids with heterocyclic alkaloids and their derivatives

摘要: G-Quadruplex nucleic acids or G-quadruplexes (G4s) are four-stranded DNA RNA secondary structures that formed in guanine-rich sequences. They widely distributed functional regions of the human genome, such as telomeres, ribosomal (rDNA), transcription start sites, promoter and untranslated mRNA, suggesting G-quadruplex may play a pivotal role control variety cellular processes. G-Quadruplexes viewed valid therapeutic targets cancer diseases. Small molecules, from naturally occurring to synthetic, exploited specifically target have proven be new class anticancer agents. Notably, alkaloids an important source ligands significant bioactivities therapy. In this review, authors provide brief, up-to-date summary heterocyclic their derivatives targeting G-quadruplexes.