Inducing immune responses to influenza virus using polypeptide and nucleic acid compositions

作者: Pamuk A. Bilsel , Jeffery L. Alexander , Mark J. Newman

DOI:

关键词:

摘要: The present invention provides polynucleotides and polypeptides capable of enhancing the immune response a human in need protection against influenza virus infection by administering vivo, into tissue human, at least one polynucleotide comprising or more regions nucleic acid encoding an protein fragment, variant, derivative thereof, polypeptide encoded therefrom. also relates to identifying preparing epitopes such epitopes. compositions methods use prevention treatment infection.

参考文章(159)
Michael L. Silver, Hwai-Chen Guo, Jack L. Strominger, Don C. Wiley, Atomic structure of a human MHC molecule presenting an influenza virus peptide. Nature. ,vol. 360, pp. 367- 369 ,(1992) , 10.1038/360367A0
Ian D. Gust, Alan W. Hampson, Daniel Lavanchy, Planning for the next pandemic of influenza. Reviews in Medical Virology. ,vol. 11, pp. 59- 70 ,(2001) , 10.1002/RMV.301
James Stevens, Adam L Corper, Christopher F Basler, Jeffery K Taubenberger, Peter Palese, Ian A Wilson, Structure of the Uncleaved Human H1 Hemagglutinin from the Extinct 1918 Influenza Virus Science. ,vol. 303, pp. 1866- 1870 ,(2004) , 10.1126/SCIENCE.1093373
Alessandro Sette, Howard M Grey, Chemistry of peptide interactions with MHC proteins Current Opinion in Immunology. ,vol. 4, pp. 79- 86 ,(1992) , 10.1016/0960-9822(92)90508-8
M. Tollis, L.D. Trani, Recent Developments in Avian Influenza Research: Epidemiology and Immunoprophylaxis Veterinary Journal. ,vol. 164, pp. 202- 215 ,(2002) , 10.1053/TVJL.2002.0716
Suryaprakash Sambhara, Anjna Kurichh, Renata Miranda, Terrence Tumpey, Thomas Rowe, Mary Renshaw, Rita Arpino, Alan Tamane, Ali Kandil, Olive James, Brian Underdown, Michel Klein, Jacqueline Katz, David Burt, Heterosubtypic Immunity against Human Influenza A Viruses, Including Recently Emerged Avian H5 and H9 Viruses, Induced by FLU–ISCOM Vaccine in Mice Requires both Cytotoxic T-Lymphocyte and Macrophage Function Cellular Immunology. ,vol. 211, pp. 143- 153 ,(2001) , 10.1006/CIMM.2001.1835
Maaike E. Ressing, Willemien J. van Driel, Remco M. P. Brandt, Gemma G. Kenter, Joan H. de Jong, Thomas Bauknecht, Gert-Jan Fleuren, Peter Hoogerhout, Rienk Offringa, Alessandro Sette, Esteban Celis, Howard Grey, Baptist J. Trimbos, W. Martin Kast, Cornelis J. M. Melief, Detection of t helper responses, but not of human papillomavirus-specific cytotoxic t lymphocyte responses, after peptide vaccination of patients with cervical carcinoma Journal of Immunotherapy. ,vol. 23, pp. 255- 266 ,(2000) , 10.1097/00002371-200003000-00010
Kuo-Chen Chou, Prediction of tight turns and their types in proteins. Analytical Biochemistry. ,vol. 286, pp. 1- 16 ,(2000) , 10.1006/ABIO.2000.4757
Dean R. Madden, Joan C. Gorga, Jack L. Strominger, Don C. Wiley, The three-dimensional structure of HLA-B27 at 2.1 Å resolution suggests a general mechanism for tight peptide binding to MHC Cell. ,vol. 70, pp. 1035- 1048 ,(1992) , 10.1016/0092-8674(92)90252-8