Staple and semi-staple oligonucleotides, method of preparation and applications

摘要: Staple and semi-staple oligonucleotides useful as anti-sense molecules in cosmetics, diagnosis especially pharmacology, methods of preparation such molecules. The staple the present invention are oligonucleotide type molecules, 3' terminal or two 5' terminals being engaged intramolecular hydrogen bindings between pairs complementary bases. As a result,these better able to withstand exonuclease attacks act with greater durability an factor than corresponding nuclear oligonucleotides.