Evaluation of Bias and Validation of Survival Estimates in a Large Cohort of AIDS Patients Treated with Zidovudine

摘要: As the epidemic of Acquired Immunodeficiency Syndrome (AIDS) has escalated over last eight years, need to find effective therapy become increasingly more urgent. AIDS appears a very high mortality rate, and majority than 30,000 reported deaths in U.S. have occurred among persons less 40 years old.1 most important health issue our time, social political issues surrounding been widely debated all segments society. The Food Drug Administration (FDA) relaxed its usual regulatory stance an effort allow possibly therapies be made available patients as quickly possible. urgency problem activism virtually impossible two double-blind placebo-controlled clinical trials normally required demonstrate efficacy safety potential therapy. It clear that epidemiologic methods will validating extending data obtained from traditional trials. is vital we develop validate these so they can provide accurate assessment benefit any therapeutic agent.