Allogeneic reconstitution after nonmyeloablative conditioning: mitigation of graft-versus-host and host-versus-graft reactivity by anti-CD44v6
作者： Ursula Günthert , Margot Zöller , Margot Zöller , Dirk-Steffen Schmidt , Oliver Christ
DOI: 10.1189/JLB.71.1.33
关键词:
摘要: T-cell maturation is accelerated in transgenic mice expressing rat CD44v4-v7 on T cells, the effect being blocked by anti-CD44v6. This finding suggested functional activity of CD44v6 thymocyte development. We tested hypothesis antibody blocking and using with targeted deletion CD44v6/v7 exon products (CD44v6/v7(-/-)). When lethally irradiated CD44v6/v7-competent (CD44v6/v7(+/+)) were reconstituted syngeneically, higher numbers CD44v6/v7(-/-) than CD44v6/v7(+/+) BMC required for survival, period reconstitution was prolonged, regain immunocompetence delayed. Similar findings observed irradiated, anti-CD44v6-treated syngeneic hosts. Thus, supports expansion hematopoietic progenitor cells. Surprisingly, or anti-CD44v6 treatment nonlethally allogeneic host had only a minor impact survival rates. hosts received an graft, rates improved. These phenomena have been result reduced GvH reactivities when donor HvG host. although deficit blockade has negative reconstitution, transient will be benefit allogeneically because strong reduction reactivities.
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