Plasmodium falciparum: effects of amantadine, an antiviral, on chloroquine-resistant and -sensitive parasites in vitro and its influence on chloroquine activity
作者： Sandra Gail Evans , Ivan Havlik
DOI: 10.1016/0006-2952(93)90264-W
关键词:
摘要: The lysosomotropic nature of amantadine suggested potential as an antimalarial. Sensitivity tests to hydrochloride alone and in combination with chloroquine were carried out 96-well microtitre plates using the tritiated hypoxanthine uptake method measure parasite growth. Amantadine has antimalarial activity. is more potent against chloroquine-resistant strains. Combinations result slight synergy both resistant sensitive
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