Pharmacokinetics of MDMA

摘要: Effects of MDMA usually begin 30–45 min after oral administration a 75–150 mg dose with peak effects occurring 60–90 ingestion, which start to diminish 2 h, however lasting up 8 h (Table 3). The time maximum concentration (Tmax) is ingestion 50, 75, or 125 mg. half-life shows little variation wide range doses. After 50-, 75-, 125-mg dose, the [49]. Other studies found be 9.53 75-mg and 9.12 [50]. (Cmax) appears dependent. A Cmax 105.6 ng/ml was reported in single subject who took 50-mg [51], whereas 330 another 135 [52]. In group eight subjects, values 75 were 126.5 226.3 ng/ml, respectively [50], 130.9 236.4 obtained mg, These indicate, that exhibits slightly greater-than-expected increase compared dose. According these observations, following usual recreational 100–150 should 200–300 ng/ml. area under concentration-time curve (AUC) data from also suggests nonlinearity. AUC measured over 24 (2,235.9 µg/l/h) more than twice (995.4 µg/l/h Nonlinearity further supported by other evidence, ratio 1:3 (50 150 mg), greater 1:10. authors suggested non-renal clearance