Striatal D2 Dopamine Receptor Characteristics in Neuroleptic-Naive Schizophrenic Patients Studied With Positron Emission Tomography

摘要: Background: According to the D 2 dopamine receptor hypothesis of schizophrenia, there is an increased number receptors in brains schizophrenic patients than those healthy controls. We tested this 13 newly admitted neuroleptic-naive and 10 volunteers using positron emission tomography. Method: The quantification striatal density (B max ) affinity (K d was done equilibrium model described for raclopride labeled with carbon 11. Results: No statistically significant alterations were found densities or affinities between patient control groups. However, a subgroup four relatively high identified. Two patients, especially, had almost twice as mean B value. K values also tended be higher subset consistent laterality observed association left striatum mass injected scan low-specific radioactivity but not Conclusion: There are no general changes schizophrenics, may aberrant characteristics vivo.