Antigen-based immunotherapy (AIT) for autoimmune and allergic disease

摘要: Autoimmune and allergic diseases are major causes of morbidity. Antigen-based immunotherapy (AIT) is immunologically the most satisfying means specifically targeting only those T cells driving disease, thereby inducing antigen-specific immune tolerance, with lowest adverse risk profile. AIT highly effective in rodent models cell-driven inflammation now clinical trials. The range approaches to applying clinic prevents a consensus on molecular basis for this form tolerance. In particular, there has been paucity information how pre-activated effector memory respond AIT. New, advanced murine beginning deliver such at cellular, biochemical, transcriptional epigenetic levels.