Immune response to staphylococcal superantigens.

摘要: Staphylococcal exotoxins, staphylococcal enterotoxins A-E (SEA-SEE), and toxic shock syndrome toxin- (TSST-1) are potent activators of the immune system cause a variety diseases in humans, ranging from food poisoning to shock. These toxins called superantigens because their ability polyclonally activate T cells at picromolar concentrations. Superantigens bind both MHC class II molecules specific Vbeta regions cell receptor, leading activation antigen-presenting lymphocytes. interactions lead excessive production proinflammatory cytokines proliferation, causing clinical symptoms that include fever, hypotension, Recent studies suggest may also be involved pathogenesis arthritis other autoimmune disorders. This review summarizes vitro vivo effects TSST-1, recent progress with use transgenic knockout mice identify key mediators receptors superantigen-induced shock, therapeutic agents mitigate superantigens.