Lipid-core nanocapsules as a nanomedicine for parenteral administration of tretinoin: development and in vitro antitumor activity on human myeloid leukaemia cells.

摘要: Tretinoin-loaded conventional nanocapsules have showed a significant protection of this drug against UVC radiation. However, formulation presents limited stability on storage. We hypothesized that the association tretinoin to lipid-core could increase physicochemical such formulations, focusing development reliable nanomedicine for parenteral administration. advantage should still be accompanied by known photoprotective effect polymeric exposure UV Results tretinoin-loaded improved formulations under storage, without changing their ability protect either UVA or In addition, nanoencapsulation antiproliferative and differentiation properties was studied human myeloid leukemia cells (HL60 cells) showing longer antitumor efficiency compared free tretinoin. These results allow us propose current (tretinoin-loaded nanocapsules) as promising treatment acute promyelocytic leukaemia.