The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

作者: Michael S Brown , Joseph L Goldstein

DOI: 10.1016/S0092-8674(00)80213-5

关键词:

摘要: Animal cells must regulate their biosynthetic pathways so as to produce the required amounts of end-products without risking overproduction. Such control is particularly important in …

参考文章(63)
R. Gordon Gould, C. Bruce Taylor, Joanne S. Hagerman, Irving Warner, Donald J. Campbell, Cholesterol metabolism. I. Effect of dietary cholesterol on the synthesis of cholesterol in dog tissue in vitro. Journal of Biological Chemistry. ,vol. 201, pp. 519- 528 ,(1953) , 10.1016/S0021-9258(18)66206-4
Bruce T. Lamb, Presenilins, amyloid-β and Alzheimer's disease Nature Medicine. ,vol. 3, pp. 28- 29 ,(1997) , 10.1038/NM0197-28
L Liscum, J Finer-Moore, R M Stroud, K L Luskey, M S Brown, J L Goldstein, Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum. Journal of Biological Chemistry. ,vol. 260, pp. 522- 530 ,(1985) , 10.1016/S0021-9258(18)89764-2
Joseph L. Goldstein, Michael S. Brown, Xiaodong Wang, Ryuichiro Sato, Jianxin Yang, Y. K. Ho, Mark J. Evans, Assignment of the Membrane Attachment, DNA Binding, and Transcriptional Activation Domains of Sterol Regulatory Element-Binding protein-1 (SREBP-1) Journal of Biological Chemistry. ,vol. 269, pp. 17267- 17273 ,(1994) , 10.1016/S0021-9258(17)32550-4
Rudolf Schoenheimer, Fritz Breusch, Synthesis and destruction of cholesterol in the organism. Journal of Biological Chemistry. ,vol. 103, pp. 439- 448 ,(1933) , 10.1016/S0021-9258(18)75823-7
Marvin D. Siperstein, Violet M. Fagan, Feedback Control of Mevalonate Synthesis by Dietary Cholesterol Journal of Biological Chemistry. ,vol. 241, pp. 602- 609 ,(1966) , 10.1016/S0021-9258(18)96879-1
E.H. Olender, R.D. Simon, The intracellular targeting and membrane topology of 3-hydroxy-3-methylglutaryl-CoA reductase. Journal of Biological Chemistry. ,vol. 267, pp. 4223- 4235 ,(1992) , 10.1016/S0021-9258(19)50651-2