Effect of drug and diet treatment of mild hypertension on diastolic blood pressure. The TAIM Research Group.
作者： H G Langford , B R Davis , D Blaufox , A Oberman , S Wassertheil-Smoller
关键词:
摘要: The Trial of Antihypertensive Interventions and Management is a multicenter randomized trial designed to examine the diastolic blood pressure response various combinations pharmacological dietary interventions in treatment mild hypertension (diastolic 90-100 mm Hg). Eight hundred seventy-eight participants at 110-160% ideal weight were randomly allocated nine drug/diet groups receiving either placebo, chlorthalidone (25 mg), or atenolol (50 combined with usual, loss, low sodium/high potassium diet. primary outcome was change from baseline 6 months. Seven eighty-seven had follow-up data. mean 93.8 Hg; 55.9% male, loss diet group lost an average 4.7 kg. Multiple comparisons accounted for analysis. A significantly greater lowering (12.4 Hg) achieved compared (7.9 Hg, p = 0.001) (8.8 0.006). Adding enhanced (15.1 when diuretic alone (10.8 0.002), but adding (12.2 0.029) did not. In short-term where sole consideration, drugs outperform diet, beneficial, especially diuretics.
sci-hub.se 参考文章(16)
Barry R. Davis, M.Donald Blaufox, C.Morton Hawkins, Herbert G. Langford, Albert Oberman, Charles Swencionis, Sylvia Wassertheil-Smoller, Judy Wylie-Rosett, Neal Zimbaldi, Trial of antihypertensive interventions and management: Design, methods, and selected baseline results☆ Controlled Clinical Trials. ,vol. 10, pp. 11- 30 ,(1989) , 10.1016/0197-2456(89)90016-0
G.A. Macgregor, G.A. Sagnella, N.D. Markandu, D.R.J. Singer, F.P. Cappuccio, Double-blind study of three sodium intakes and long-term effects of sodium restriction in essential hypertension. The Lancet. ,vol. 334, pp. 1244- 1247 ,(1989) , 10.1016/S0140-6736(89)91852-7
Stephen W. MacMahon, Jeffrey A. Cutler, Curt D. Furberg, Gerald H. Payne, The effects of drug treatment for hypertension on morbidity and mortality from cardiovascular disease: A review of randomized controlled trials Progress in Cardiovascular Diseases. ,vol. 29, pp. 99- 118 ,(1986) , 10.1016/0033-0620(86)90038-1
S. W. MacMahon, G. J. Macdonald, L. Bernstein, G. Andrews, R. B. Blacket, A RANDOMIZED CONTROLLED TRIAL OF WEIGHT REDUCTION AND METOPROLOL IN THE TREATMENT OF HYPERTENSION IN YOUNG OVERWEIGHT PATIENTS Clinical and Experimental Pharmacology and Physiology. ,vol. 12, pp. 267- 271 ,(1985) , 10.1111/J.1440-1681.1985.TB02645.X
R Brian Haynes, Andrew C. Harper, Samuel R. Costley, Mary Johnston, Alexander G. Logan, Patrick T. Flanagan, David L. Sackett, Failure of weight reduction to reduce mildly elevated blood pressure: a randomized trial. Journal of Hypertension. ,vol. 2, pp. 535- 539 ,(1984) , 10.1097/00004872-198410000-00014
Stevo Julius, The Association of Borderline Hypertension With Target Organ Changes and Higher Coronary Risk JAMA. ,vol. 264, pp. 354- 358 ,(1990) , 10.1001/JAMA.1990.03450030078036
Albert Oberman, Sylvia Wassertheil-Smoller, Herbert G Langford, M Donald Blaufox, Barry R Davis, Thomas Blaszkowski, Neal Zimbaldi, C Morton Hawkins, Pharmacologic and Nutritional Treatment of Mild Hypertension: Changes in Cardiovascular Risk Status Annals of Internal Medicine. ,vol. 112, pp. 89- 95 ,(1990) , 10.7326/0003-4819-112-2-89
Anders Helgeland, Treatment of mild hypertension: A five year controlled drug trial: The Oslo study The American Journal of Medicine. ,vol. 69, pp. 725- 732 ,(1980) , 10.1016/0002-9343(80)90438-6
Norman M. Kaplan, Maximally Reducing Cardiovascular Risk in the Treatment of Hypertension Annals of Internal Medicine. ,vol. 109, pp. 36- 40 ,(1988) , 10.7326/0003-4819-109-1-36
Alexander G. Logan, Sodium manipulation in the management of hypertension. The view against its general use Canadian Journal of Physiology and Pharmacology. ,vol. 64, pp. 793- 802 ,(1986) , 10.1139/Y86-136