Use of quantitative MRI for the detection of progressive cartilage degeneration in a mini‐pig model of osteoarthritis caused by anterior cruciate ligament transection

摘要: Background: To investigate the progression of cartilage degeneration using delayed gadolinium-enhanced MRI (dGEMRIC) and T2 mapping in a mini-pig model osteoarthritis (OA) caused by anterior cruciate ligament transection (ACLT). Methods: Twelve mini-pigs underwent ACLT left knee were monitored dGEMRIC (T1, gadolinium [Gd]) after 2, 4, or 6 weeks (n 54 each). No surgery was performed four healthy control mini-pigs, which also mapping. Cartilage samples from weight-bearing regions medial femoral condyles collected for macroscopic, histological, immunohistochemical, biochemical analysis. Correlations between contents T1,Gd values evaluated Pearson correlation Results: gradually reduced increased over time. surfaces showed roughness at 4 additional defects weeks. Glycosaminoglycan (GAG) distribution content time (P <0.05), collagen anisotropy obviously changed However, did not differ significantly among postoperative timepoints. GAG positively related to (r 50.888; P <0.001) negatively 52 0.865; <0.001). Collagen had no discernible with values. Conclusion: can monitor ACLT-induced OA, permitting early detection OA. J. MAGN. RESON. IMAGING 2015;00:000–000.