High pressure studies on the misfolding and aggregation of p53 in cancer and of α-synuclein in Parkinson’s disease
作者： Guilherme A. P. de Oliveira , Mayra A. Marques , Murilo M. Pedrote , Jerson L. Silva
DOI: 10.1080/08957959.2019.1576173
关键词:
摘要: ABSTRACTHigh pressure research can be used to aid in answering why some polypeptide chains reversibly unfold and others adopt a misfolding conformation culminating aggregation. This topic is one of the fundamental questions biology that we seek understand, for that, have been experimentally applying proteins last 20 years. Here, exemplify how should identify preamyloidogenic protein intermediates as well dissociate supramolecular complexes. We believe applications high understand behavior are diverse help biologists answer biomedical relevance.
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